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目的观察阿魏酸钠治疗不稳定型心绞痛(UAP)的疗效。方法选择2005年3月至2008年3月辽宁省朝阳市双塔区院内科住院的62例UAP患者,随机分为2组,治疗组30例,对照组30例。两组均接受阿司匹林,硝酸脂类,β-受体阴滞剂,钙离子拮抗剂及肝素等常规治疗,治疗组加用阿魏酸钠0.3g静脉滴注,每日1次,疗程14d。对照加用复方丹参注射液16mL静脉滴注,每日1次,疗程14d。结果心绞痛缓解情况:治疗组总有效率87%,对照组总有效率59%,两组疗效差异有统计学意义(P<0.05)。心电图改善情况:治疗组总有效率73%,对照组总有效率53%(P<0.05)。12导联心电图ΣST(mm)治疗组:治疗前(3.14±1.2)mm,治疗后(1.7±1.4)mm,(P<0.05),对照组治疗前ΣST,对照组治疗前ΣST(3.3±1.4)mm,治疗后(2.3±1.2)mm(P>0.05)。结论阿魏酸钠治疗不稳定型心绞痛有效。
Objective To observe the efficacy of sodium ferulate in the treatment of unstable angina pectoris (UAP). Methods Sixty-two patients with UAP who were hospitalized in Shuangta District Hospital of Chaoyang City, Liaoning Province from March 2005 to March 2008 were randomly divided into two groups: 30 cases in the treatment group and 30 cases in the control group. The two groups were given aspirin, nitric acid lipids, β-receptor blockers, calcium antagonists and heparin and other conventional treatment, the treatment group with sodium ferulate 0.3g intravenous infusion, once daily for 14 days. Control plus compound Danshen injection 16mL intravenous infusion, 1 day, treatment 14d. Results Angina relief: The total effective rate was 87% in the treatment group and 59% in the control group, with significant difference between the two groups (P <0.05). ECG improvement: the total effective rate was 73% in the treatment group, the control group, the total effective rate was 53% (P <0.05). Before treatment, the mean value of ΣST in control group was (3.3 ± 1.4) mm, after treatment (1.7 ± 1.4) mm, (P <0.05) ) mm, after treatment (2.3 ± 1.2) mm (P> 0.05). Conclusion Sodium ferulate is effective in treating unstable angina pectoris.