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目的测定2型糖尿病(T2DM)男性患者血清睾酮和血脂水平,并校正传统混杂因素及甲状腺功能,以探讨睾酮与血脂之间的相关性。方法检测125例T2DM男性患者总睾酮(TT)、卵泡刺激素(FSH)、黄体生成素(LH)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,并计算TT/LH(TSI)比值。通过简单相关、偏相关及多元线性回归分析探讨睾酮与血脂之间的相关性。根据TT四分位数将T2DM男性患者分为4组(A组:TT<3.93 ng/mL;B组:TT 3.93~5.09 ng/mL;C组:TT 5.10~6.58 ng/mL;D组:TT>6.58 ng/mL),应用单因素方差分析比较组间血脂水平。结果相关及多元线性回归分析显示,TT与TG呈显著负相关(P<0.05),与HDL-C呈显著正相关(P<0.05);TSI与TG呈显著负相关(P<0.05)。ANOVA结果显示,与最低TT水平A组相比,B、C、D组的TG水平均显著降低(P<0.05),C、D组HDL-C水平则显著升高(P<0.05)。结论 T2DM男性患者血清睾酮与TG呈负相关,与HDL-C呈正相关,提示雄性激素可能对T2DM男性患者的血脂代谢异常具有保护作用。
Objective To determine the level of serum testosterone and serum lipids in type 2 diabetes mellitus (T2DM) male patients and to correct the traditional confounding factors and thyroid function to explore the correlation between testosterone and blood lipids. Methods The total testosterone (TT), follicle stimulating hormone (FSH), luteinizing hormone (LH), cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) High-density lipoprotein cholesterol (HDL-C) levels, and calculated TT / LH (TSI) ratio. Correlation between testosterone and lipids was explored by simple correlation, partial correlation and multiple linear regression analysis. According to TT quartiles, T2DM male patients were divided into 4 groups (group A: TT <3.93 ng / mL; group B: TT 3.93-5.09 ng / mL; group C: TT 5.10-6.58 ng / mL; TT> 6.58 ng / mL). One-way analysis of variance (ANOVA) was used to compare the plasma lipid levels. Results Correlation and multivariate linear regression analysis showed that there was a significant negative correlation between TT and TG (P <0.05) and HDL-C (P <0.05). TSI was negatively correlated with TG (P <0.05). The results of ANOVA showed that compared with the lowest TT level in group A, TG levels in groups B, C and D were significantly decreased (P <0.05), and levels of HDL-C in groups C and D were significantly increased (P <0.05). Conclusions Serum testosterone is negatively correlated with TG in male patients with T2DM and is positively correlated with HDL-C, suggesting that androgens may have protective effects on dyslipidemia in T2DM male patients.