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采用肉汤稀释法和纸片法测定９４株临床分离病原菌对β－内酰胺抗生素的敏感性和检测病原菌的β－内酰胺酶５０株（５３．２％）对氨苄青霉素耐药，其中４７株（９６．０％）β－内酰胺酶阳性；对舒他西林耐药６株（６．４％），５株检出β－内酰胺酶对头孢噻肟耐药３株（３．２％），２株含β－内酰胺酶表明β－内酰胺酶的产生是金葡球菌、大肠杆菌、肺炎杆菌及其它杆菌耐上述三种β－内酰胺抗生素的主要原因。因此，β－内酰胺酶的测定，对临床合理应用抗生素具有重要意义，β－内酰胶酶抑制剂与β－内酰胺抗生素联用是治疗耐药菌的有效途径之一。
The sensitivity of β-lactam antibiotics to 94 strains of clinical isolates and 50 strains of β-lactamases (53.2%) to detect pathogenic bacteria were tested against ampicillin using broth dilution method and disk method. Among them, 47 strains (96.0%) were positive for β-lactamase; 6 (6.4%) were resistant to sultamicillin; 3 were resistant to cefotaxime (3% ), Two strains containing β-lactamase showed that the production of β-lactamase was caused by Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and other bacilli and was the main cause of the above three β-lactam antibiotics. Therefore, the determination of β-lactamase, clinically rational use of antibiotics is important, β-lactamase inhibitor and β-lactam antibiotics is an effective way to treat drug-resistant bacteria.