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目的探讨血清C-反应蛋白(CRP)与2型糖尿病视网膜病变的关系。方法将132例2型糖尿病根据眼底结果分糖尿病组、单纯型DR组、增殖型DR组测定血清CRP水平,并与糖脂代谢指标作相关分析。结果CRP水平糖尿病组与糖尿病DR有显著差异(P<0.05),且随病程延长而升高,CRP水平与血糖、HbA1c、BMI、TC、TG、LDL-C呈正相关(P<0.05)。结论提示CRP可能与2型糖尿病应网膜病变的发生、发展有一定相关性。
Objective To investigate the relationship between serum C-reactive protein (CRP) and type 2 diabetic retinopathy. Methods 132 cases of type 2 diabetes mellitus were divided into diabetic group, simple DR group and proliferative DR group to determine serum CRP level according to the fundus findings, and the correlation was analyzed with the index of glucose and lipid metabolism. Results There was a significant difference (P <0.05) between the CRP level and diabetic DR group and with the prolongation of the course of disease. The CRP level was positively correlated with the levels of blood glucose, HbA1c, BMI, TC, TG and LDL-C (P <0.05). Conclusions CRP may be associated with the occurrence and development of type 2 diabetic retinopathy.