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闭锁综合征(lock-in-syndrome)是一种以脑桥基底部受损的多原因造成的综合征,预后不良,病死率高。其病因以脑血管病为主,占75%,其中脑干梗死占60%,其他少见的病因包括脑桥出血、肿瘤、脱髓鞘病、脑干脑炎、脑桥中央髓鞘溶解症或头部外伤。笔者自1999年10月～2011年5月共诊治3例,报道如下。
Lock-in-syndrome is a syndrome characterized by multiple causes of impaired basal pons, with poor prognosis and high mortality. The main cause of cerebrovascular disease, accounting for 75%, including cerebral infarction accounted for 60%, other rare causes include pontine hemorrhage, tumor, demyelinating disease, encephalitis, pontine myelinolysis or head trauma. The author from October 1999 to May 2011 a total of 3 cases were treated, reported as follows.