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为探讨酒精所致的神经元分化成熟迟滞和髓鞘形成受阻机制，本文以ＤＰＨ荧光探针研究了酒精对与神经元和髓鞘发育相关的星形胶质细胞、少突胶质细胞膜脂质流动性的影响。结果表明５ｍｍｏｌ／Ｌ酒精可导致星形胶质细胞、少突胶质细胞ＤＰＨ荧光探针的荧光偏振度（Ｐｒ）降低，膜脂质流动度（ＬＦＵ）增高，呈明显的剂量－反应关系，并发现酒精对星形胶质细胞作用强于少突胶质细胞。上述结果揭示酒精能改变两种胶质细胞的膜脂质流动性。它可能在酒精所致的神经元和髓鞘功能发育异常中起重要作用。
In order to investigate the retardation of maturation and myelination caused by alcohol, we used DPH fluorescence probe to study the effect of alcohol on neuronal and myelin development-related astrocytes, oligodendrocyte membrane lipid Influence of liquidity. The results showed that 5 mmol / L alcohol could induce the decrease of fluorescence polarization (DP) and LPU of astrocyte and oligodendrocyte DPH fluorescent probe, showing a dose-response relationship, And found that alcohol on astrocytes stronger than oligodendrocytes. The above results revealed that alcohol can alter membrane lipid fluidity of both glial cells. It may play an important role in alcohol-induced neuronal and myelin dysplasia.