本文采用气相色谱法分离并测定了生物样品中莱曼宁的浓度,研究了莱曼宁在动物体内的吸收、分布和排泄过程。小鼠ig莱曼宁后的吸收速率常数为0.73h~(-1)。大鼠4h的胆汁排泄量仅为给药量的0.6％,大鼠尿中32h排泄量为给药量的13.3％。大鼠iv给药后体内过程符合二房室特征。大鼠体内分布以肾脏最高,其次为脾、肝、心、脑,外周组织如脂、肌含量较少。莱曼宁与兔血浆蛋白的结合率为49.2％。 In this paper, gas chromatography was used to separate and determine the concentration of Lymanning in biological samples. The absorption, distribution and excretion of Lymanining in animals were studied. The absorption rate constant of ig Lamanin in mice was 0.73 h ~ (-1). 4h rat bile excretion was only 0.6% of the dose, rat urine 32h excretion of 13.3% of the dose. In Vivo Procedures After iv administration in rats, two-chamber characteristics were met. Rat body distribution to the highest kidney, followed by the spleen, liver, heart, brain, peripheral tissue such as fat, less muscle content. The binding rate of Lymanning to rabbit plasma protein was 49.2%.