论文部分内容阅读
目的通过血清中肿瘤标志糖蛋白抗原 (CA) 72 - 4和 CA12 5的检测 ,观察其阳性检出率与卵巢上皮性恶性肿瘤的关系。方法卵巢上皮性恶性肿瘤患者 38例和良性肿瘤患者 6 4例的血清样品 ,分别用酶联免疫吸附试验 (EL SIA)和化学发光测定 CA72 - 4和 CA12 5。结果与良性组相比 ,卵巢上皮性恶性肿瘤 ,CA72 - 4、CA12 5和CA72 - 4和 /或 CA12 5的灵敏度分别为 78.9%、6 5 .8%和 89.5 % ,其特异性为 39.1～ 6 8.8% ,卡方检验统计 ,P<0 .0 5差异有显著性 ;在卵巢上皮性肿瘤的分类中 ,CA72 - 4在粘液性和内膜样 ,CA12 5在浆液性和粘液性 ,以及CA72 - 4和 /或 CA12 5在粘液性囊腺癌 (瘤 )的良恶性统计比较 ,P<0 .0 5 ,差异有显著性 ,其中 CA72 - 4在粘液性和内膜样囊腺癌及 CA12 5在浆液性囊腺癌获得较高的检出率 (75 .0～ 89.5 % )。结论 2项肿瘤标志对卵巢上皮性肿瘤的良恶性辅助及鉴别诊断具有一定的应用价值 ,CA72 - 4优于 CA12 5
Objective To investigate the relationship between the positive detection rate of epithelial ovarian cancer and ovarian cancer by measuring the serum tumor markers glycoprotein antigen (CA) 72 - 4 and CA12 5. Methods Serum samples from 38 patients with epithelial ovarian cancer and 64 patients with benign tumor were tested for CA72 - 4 and CA12 5 using EL SIA and chemiluminescence, respectively. Results The sensitivity of ovarian epithelial malignancies CA72 - 4, CA12 5, CA72 - 4 and / or CA12 5 was 78.9%, 65.8% and 89.5%, respectively, with a specificity of 39.1 ~ 6 8.8%, chi square test statistics, P <0. 05 differences were significant; in the classification of epithelial ovarian cancer, CA72 - 4 in mucinous and endometrial like, CA12 5 in serous and mucinous, and There were significant differences between benign and malignant mucinous cystadenocarcinomas (CA72 - 4) and / or CA12 5 (P <0.05). There was a significant difference between CA72 - 4 and mucinous cystadenocarcinoma CA12 5 in serous cystadenocarcinoma to obtain a higher detection rate (75.0 ~ 89.5%). Conclusions The two tumor markers have some value in the diagnosis and differential diagnosis of benign and malignant ovarian epithelial tumors. CA72 - 4 is superior to CA12 5