壳聚糖(chitosan)具有多种生物活性,如增强机体免疫力、激活免疫细胞等。近年来更多研究发现壳聚糖在炎症性疾病的治疗中起着重要作用,表明壳聚糖能弱化炎症处激活的免疫细胞,减轻免疫细胞浸润。本文将论述壳聚糖对一种重要的免疫细胞—巨噬细胞的双向免疫调节作用,以期为新型免疫调节药物的开发利用提供新的思路。 Chitosan has a variety of biological activities, such as enhancing immunity and activating immune cells. In recent years, more studies have found that chitosan plays an important role in the treatment of inflammatory diseases, indicating that chitosan can weaken the inflammatory cells activated immune cells, reduce immune cell infiltration. This article will discuss the two-way immunomodulatory effect of chitosan on an important immune cell-macrophage, with a view to providing new ideas for the development and utilization of new immunomodulatory drugs.