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已经证明一些细胞象脾淋巴细胞、血T细胞、自然杀伤细胞和血小板存在有阿片受体。本文在骨髓细胞上的研究提示未成熟B细胞表面也存在有这类神经肽的受体,通过阿片肤类结合到细胞上可以观察到不同的效应。试验结果显示M-脑啡肽、L-脑啡肽和α-内啡肽对骨髓未成熟B细胞抗体生成反应的抑制分别为76.6％、68.6％和67.7％。相反,β-内啡肽增进抗体反应达78.0％。M-脑啡肽和两种内啡肽在未成熟B细胞上的效应能够被拮抗剂纳络酮所逆转,提示反应涉及阿片肽受体机制。
Some cells have been shown to have opioid receptors such as splenic lymphocytes, blood T cells, natural killer cells, and platelets. Our study on myeloid cells suggests that there are receptors for these neuropeptides on the surface of immature B cells, and different effects can be observed by opioid binding to cells. The results showed that the inhibitory effects of M-enkephalin, L-enkephalin and α-endorphin on bone marrow immature B cell antibody production were 76.6%, 68.6% and 67.7%, respectively. In contrast, beta-endorphin increased the antibody response by 78.0%. The effect of M-enkephalin and both endorphins on immature B cells can be reversed by the antagonist naloxone, suggesting that the response involves the opioid receptor mechanism.