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目的观察颅内感染患者血清和脑脊液中神经元特异性烯醇化酶(NSE)的含量变化并探讨其意义。方法应用放免法测定40例颅内感染患者:病毒性脑炎(病脑)18例,结核性脑膜炎(结脑)14例,化脓性脑膜炎(化脑)8例和对照组23例的血清及脑脊液中NSE含量。结果无论在脑脊液还是在血清中,观察组的NSE含量均显著高于对照组(P<0.05);NSE含量依次为病脑>结脑>化脑(P<0.05);血清和脑脊液中含量呈正相关(P<0.01)。结论颅内感染患者血清和脑脊液中NSE含量与脑损害程度密切相关;测定血清中NSE含量可以作为判断脑损害程度的简便观察指标。
Objective To observe the changes of neuron specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of patients with intracranial infection and to explore its significance. Methods: Forty patients with intracranial infection were detected by radioimmunoassay: eighteen cases of viral encephalitis (encephalitis), 14 cases of tuberculous meningitis (tuberculous meningitis), eight cases of purulent meningitis (mesencephalic brain) and 23 cases of control group Serum and CSF NSE levels. Results The levels of NSE in the observation group were significantly higher than those in the control group (P <0.05), and the levels of NSE in the cerebrospinal fluid (CSF) and serum (P <0.05) Related (P <0.01). Conclusion The serum levels of NSE in serum and CSF of patients with intracranial infection are closely related to the degree of brain damage. Determination of serum NSE levels can be used as a simple and convenient indicator to judge the degree of brain damage.