血管内皮生长因子 (VEGF)是最重要的血管生成促进因子 ,其主要功能有诱导血管通透性增加 ,促进血管内皮细胞迁移 ,刺激内皮细胞增殖进而促进血管生成。本文就VEGF在男性前列腺、睾丸、附睾的定位、表达调控 ,以及其变化所导致的血管生成的改变与男性生殖系统某些疾病的关系作一简要综述 Vascular endothelial growth factor (VEGF) is the most important angiogenesis promoting factor. Its main function is to induce the increase of vascular permeability, promote the migration of vascular endothelial cells, stimulate the proliferation of endothelial cells and further promote angiogenesis. This review summarizes the location, expression and regulation of VEGF in male prostate, testis and epididymis, and the relationship between the changes of angiogenesis caused by the changes and some diseases in the male reproductive system