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目的:探讨中国中年人群QT间期与出生体重及心血管危险因素的关系。方法:对974例“宫内发育与成人疾病”队列人群进行流行病学调查、身体测量、血生化指标检测,记录标准12导联心电图,用Bazett公式计算校正的QT间期(QTc),设定QTc>0.41s为QT延长,采用Logisiti回归方法分析中年人群QT间期与出生体重及心血管危险因素的关系。结果:人群QT间期延长者262例(27.0%),男女QT间期延长检出率分别为21.6%,32.6%,心血管危险因素聚集的总检出率分别为64.85%,36.33%(均P<0.01),且男性随着出生体重的增加其检出率和患病危险度呈下降趋势。单项TG升高或心血管危险因素异常聚集与QT间期延长检出率有显著相关关系(均P<0.05)。结论:在中年期,男性心血管危险因素聚集检出率明显高于女性;心血管危险因素聚集与QT间期延长有明显相关性;中年女性的QT间期延长检出率明显高于男性,且可能与出生体重低有关。
Objective: To investigate the relationship between QT interval and birth weight and cardiovascular risk factors in Chinese middle-aged population. Methods: Epidemiological investigation, physical measurement and blood biochemistry indexes were performed in 974 cohorts of “intrauterine growth and adult diseases”. The standard 12-lead electrocardiogram was recorded and the corrected QTc was calculated by Bazett’s formula. QTc> 0.41s for QT extension, the use of Logisiti regression analysis of middle-aged population QT interval and birth weight and cardiovascular risk factors. Results: 262 cases (27.0%) of QT prolongation were observed in the population. The detection rate of QT prolongation between men and women was 21.6% and 32.6% respectively. The total detection rate of cardiovascular risk factors was 64.85% and 36.33% respectively P <0.01). And with the increase of birth weight, the detection rate and the prevalence of the risk decreased. There was a significant correlation between single TG elevation or abnormal aggregation of cardiovascular risk factors and QT prolongation (all P <0.05). Conclusions: The detection rate of cardiovascular risk factors in men is significantly higher than that in women in middle age. There is a significant correlation between the aggregation of cardiovascular risk factors and QT prolongation. The detection rate of QT prolongation in middle-aged women is significantly higher than that in women Males, and may be related to low birth weight.