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目的:探讨转运前在基层医院使用肺表面活性物质(PS)对转运过程中气道的稳定作用。方法:34例高危早产儿(实验组)转运前气管内滴注PS,与34例须转运但未使用PS的早产儿(对照组)进行前瞻性临床对照研究。结果:实验组与对照组比较,途中出现血氧饱和度下降的例数显著降低,氧分压、血氧饱和度、动脉/肺泡血氧分压比值显著增加;氧疗时间、机械通气时间和住院天数显著减少(P<0.05)。结论:转运前在基层医院使用PS,可稳定早产儿气道,保证转运质量,改善早产儿临床症状,缩短氧疗时间、机械通气时间和住院天数。
OBJECTIVE: To investigate the stabilizing effects of pulmonary surfactant (PS) on the airway during transport in primary hospitals before transport. Methods: Thirty-four high-risk preterm infants (experimental group) received intratracheal intratracheal instillation of PS before transfusion, and 34 preterm infants (control group) who were transfused but did not use PS were prospectively controlled. Results: Compared with the control group, the number of oxygen saturation decreased obviously in the experimental group and the control group. The oxygen partial pressure, oxygen saturation and arterial / alveolar partial pressure ratio increased significantly. The oxygen therapy time, mechanical ventilation time and Hospitalization days were significantly reduced (P <0.05). CONCLUSIONS: PS is used in primary hospitals before transfusion to stabilize the airway of premature infants, to ensure the quality of transport, to improve the clinical symptoms of premature infants, to shorten the duration of oxygen therapy, duration of mechanical ventilation and length of stay.