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目的 研究1336例乳腺癌手术病例标本中ER、PR表达与乳腺癌生物学行为的关系。方法 用免疫组化S-P法检测1336例乳腺癌手术标本中ER、PR的表达。结果 1336例乳腺癌中ER阳性表达788例,PR表达1020例,共同阳性表达658例(49.3％);ER、PR表达与乳腺癌肿瘤大小及发病年龄无关;ER、PR阳性表达与乳腺癌TNM分期有关P<0.05;此外ER表达与乳腺癌病理学分类及腋淋巴结转移呈负相关P<0.05。结论 ER、PR参与了乳腺癌生物学行为的调控,检测ER、PR的表达情况有助于乳腺癌患者的预后评估,并且为内分泌治疗提供依据。
Objective To study the relationship between the expression of ER, PR and the biological behavior of breast cancer in 1336 breast cancer surgical specimens. Methods Immunohistochemical S-P method was used to detect the expression of ER and PR in 1336 breast cancer surgical specimens. Results Among 336 cases of breast cancer, 788 were positive for ER, 1020 were PR, and 658 were common positive (49.3%). The expression of ER and PR was not associated with breast cancer tumor size and age; ER, PR positive expression and breast cancer TNM P<0.05 for staging; ER expression was negatively correlated with breast cancer pathological classification and axillary lymph node metastasis P<0.05. Conclusion ER and PR are involved in the regulation of biological behaviors of breast cancer. Detecting the expression of ER and PR is helpful for the prognosis evaluation of breast cancer patients, and provides a basis for endocrine therapy.