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目的观察颅脑损伤患者血清中C反应蛋白(CRP)、interleukin-6(IL-6)及乳酸脱氢酶的检测水平,研究其价值。方法选取我院急性颅脑损伤患者,共170例,检测血清中CRP、IL-6及乳酸脱氢酶的表达,同时选取体检的正常成人血清标本80例作为对照组,分析其临床意义。结果结果颅脑损伤患者血清中CRP、IL-6及乳酸脱氢酶的检测水平增高(p<0.05),CRP、IL-6及乳酸脱氢酶在重型颅脑损伤患者中的表达明显高于非重型颅脑损伤患者(p<0.05),颅脑损伤患者CRP和IL-6的表达呈正相关(p<0.05)。结论结论颅脑损伤患者CRP、IL-6及乳酸脱氢酶高表达,联合检测CRP、IL-6及乳酸脱氢酶的表达对判断病情可能有一定价值,CRP和IL-6的表达具有协同作用。
Objective To observe the levels of serum C-reactive protein (CRP), interleukin-6 (IL-6) and lactate dehydrogenase in patients with craniocerebral injury and to study their value. Methods A total of 170 patients with acute craniocerebral injury were selected to detect the expression of CRP, IL-6 and lactate dehydrogenase in the serum. Meanwhile, 80 normal adult serum samples from the physical examination were selected as the control group, and their clinical significance was analyzed. Results The serum levels of CRP, IL-6 and lactate dehydrogenase were significantly increased in patients with craniocerebral injury (p <0.05). The levels of CRP, IL-6 and lactate dehydrogenase in patients with severe craniocerebral injury were significantly higher than those in patients with severe craniocerebral injury In non-severe craniocerebral injury patients (p <0.05), there was a positive correlation between CRP and IL-6 expression in patients with craniocerebral injury (p <0.05). Conclusions The expression of CRP, IL-6 and lactate dehydrogenase in patients with craniocerebral injury is high, and the combined detection of CRP, IL-6 and lactate dehydrogenase may have some value in judging the condition, and the expression of CRP and IL-6 is synergistic effect.