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目的 探讨丹参注射液对治疗妊娠晚期特发性临界性羊水过少的围产期结局的影响。方法 用随机的方法将77名患者分为对照组(38例)和治疗组(39例)。对照组采用静脉补液的方法,每日静脉输液2000ml。治疗组采用丹参注射液4ml加入右旋糖酐40葡萄糖注射液500ml+1500ml液体静脉滴注,1次/d。连续7d为1个疗程。观察羊水指数、脐动脉S/D、新生儿5minAp-gar评分、新生儿出生体重、剖宫产率、产后出血情况及凝血功能变化。结果 治疗组治疗后羊水指数较治疗前增加,并且差异有统计学意义(P<0.05);而对照组治疗后虽然比治疗前羊水指数的平均值增加,但是差异无统计学意义(P>0.05)。治疗组治疗后脐动脉S/D值较治疗前下降,并且差异有统计学意义(P<0.05)。治疗组剖宫产比率为30.1%,对照组为55.3%;治疗组发生胎儿轻度以上窒息的有6例(15.4%),对照组有12例(31.6%),差异有统计学意义(P<0.05)。治疗组新生儿平均出生体重为(3085±277)g,对照组为(2858±333)g,差异有统计学意义(P<0.05)。两组均未发生产后出血。两组在治疗前后凝血功能均无明显变化。结论 丹参对治疗妊娠晚期特发性羊水过少有一定疗效,并且不影响患者的凝血功能。
Objective To investigate the effect of Salvia miltiorrhiza injection on perinatal outcome in the treatment of late trimester idiopathic critical oligohydramnios. Methods A total of 77 patients were randomly divided into control group (38 cases) and treatment group (39 cases). Control group using intravenous rehydration method, daily intravenous infusion 2000ml. The treatment group using Danshen injection 4ml dextran 40 glucose injection 500ml + 1500ml liquid intravenous infusion, 1 time / d. Continuous 7d for a course of treatment. Amniotic fluid index, umbilical artery S / D, neonatal 5minAp-gar score, newborn birth weight, cesarean section rate, postpartum hemorrhage and coagulation changes were observed. Results After treatment, the amniotic fluid index of the treatment group increased compared with that before treatment, and the difference was statistically significant (P <0.05); while the control group after treatment, although the average value of amniotic fluid index before treatment increased, but the difference was not statistically significant (P> 0.05 ). The S / D value of umbilical artery decreased after treatment in treatment group, and the difference was statistically significant (P <0.05). The rate of cesarean section was 30.1% in the treatment group and 55.3% in the control group. Six cases (15.4%) in the treatment group had mild asphyxia than in the control group and 12 cases (31.6%) in the control group, the difference was statistically significant (P <0.05). The mean neonatal birth weight was (3085 ± 277) g in the treatment group and (2858 ± 333) g in the control group, the difference was statistically significant (P <0.05). No postpartum hemorrhage occurred in either group. There was no significant difference in coagulation between the two groups before and after treatment. Conclusion Salvia on the treatment of idiopathic trimester of pregnancy oligohydramnios have a certain effect, and does not affect the patient’s coagulation.