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目的分析TNF-α等炎性因子与重型颅脑损伤预后相关性及其临床意义。方法 2012年1月-2014年12月接诊收治的重型颅脑损伤患者120例作为观察组,本院同期体检健康的志愿者120名作为对照组,观察组按照格拉斯哥昏迷评分标准分为颅脑损伤中重型和颅脑损伤轻型各60例。分别对研究对象进行放射免疫法和酶联免疫吸附法测定血清TNF-α、IL-6、IL-8的水平,并分析其与重型颅脑损伤预后相关性。结果观察组血清的TNF-α、IL-6、IL-8的水平均高于对照组(P<0.05);中重颅脑损伤患者血清TNF-α、IL-6、IL-8水平均高于轻型颅脑损伤者(P<0.05)。1个月后,观察组格拉斯哥评分预后良好者45例,预后差者75例,预后不良的患者血清TNF-α、IL-6、IL-8的水平均高于预后良好的患者,差异均有统计学意义(P<0.05)。结论对患者的颅脑损伤程度的判定标准可以以血清中的TNF-α、IL-6、IL-8的水平为指标,并且对患者颅脑损伤的预后判定有重要意义。
Objective To analyze the relationship between inflammatory factors such as TNF-α and the prognosis of severe craniocerebral injury and its clinical significance. Methods From January 2012 to December 2014, 120 cases of severe craniocerebral injury admitted to our hospital were selected as the observation group and 120 healthy volunteers in the same period of the hospital were taken as the control group. The observation group was divided into three groups according to Glasgow coma score: 60 cases of moderate and severe injuries and 60 cases of traumatic brain injury. The levels of TNF-α, IL-6 and IL-8 in serum were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. The correlations between serum TNF-α, IL-6 and IL- Results Serum levels of TNF-α, IL-6 and IL-8 in the observation group were significantly higher than those in the control group (P <0.05). Serum levels of TNF-α, IL-6 and IL-8 in patients with moderate- In mild craniocerebral injury (P <0.05). One month later, the observation group Glasgow score of 45 patients with good prognosis, 75 patients with poor prognosis, patients with poor prognosis serum TNF-α, IL-6, IL-8 levels were higher than those with good prognosis, the difference was Statistical significance (P <0.05). Conclusion The criteria for judging the severity of craniocerebral injury in patients may be based on the levels of TNF-α, IL-6 and IL-8 in serum and have important significance in prognosis of patients with craniocerebral injury.