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低分子量肝素是新发展起来的一种生化药物，具有多种非抗凝活性。研究结果显示，LMWH16000u·L(-1)（P＜0．01）和8000u·L(-1)（P＜0．05）均能显著降低OA所致的致敏豚鼠离体回肠平滑肌收缩高度；LMWH200u·kg(-1)，50u·kg(-1)和12．5u·kg(-1)（P＜0．01）均能明显抑制颅骨骨膜肥大细胞脱颗粒；LMWH60u·kg(-1)（P＜0．01）和30u·kg（P＜0．05）均能显著减少个氨基毗陡诱发的小鼠舔体反应次数，并能抑制冰乙酸所致的小鼠毛细血管通透性增加。结果表明LMWH对多种动物模型具有抗过敏的作用，这种作用可能与其抑制肥大细胞脱颗粒和抗炎作用有关。
Low molecular weight heparin is a newly developed biochemical drug with a variety of non-anticoagulant activity. The results showed that LMWH16000u · L (-1) (P <0.01) and 8000u · L (-1) (P <0.05) both significantly reduced the contractile height of isolated ileum smooth muscle in sensitized guinea pigs ; LMWH at 200u · kg -1, 50u · kg -1 and 12.5u · kg -1 significantly inhibited the degranulation of the skull osmotic mast cells; LMWH at 60u · kg -1 ) (P <0.01) and 30u · kg (P <0.05) significantly reduced the number of lick reaction induced by aminodipeptide in mice and inhibited the capillary permeability of mice induced by glacial acetic acid Sex increases. The results showed that LMWH anti-allergic effect on a variety of animal models, this effect may be related to its inhibition of mast cell degranulation and anti-inflammatory effects.