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肿瘤病灶的发生和发展与机体自身抗感染力(包括抗感染和抗肿瘤防御因子)有密切连系。防御因子可分为特异性与非特异性二类,后者中有备解素、补体、溶菌酶等,溶菌酶存在于体液、组织和细胞内,已有报道证实上呼吸道及上消化道恶性肿瘤患者的溶菌酶活性明显受抑制。化疗、放疗也同时影响机体的免疫力。作者们为研究溶菌酶对在化-放疗过程中的口咽恶性肿瘤患者机体抗感染力的影响。曾对43例经病检证实的患者进行检查,分为两组,一组仅接受化-放疗(21例),另组22例除化-放疗外,在疗程中每日2次给0.5％溶菌酶液5 ml做气雾吸入治疗。检查方法包括用比浊法对唾液和血清内溶菌酶活性傲动态测定,对第二组患者还加做口腔大肠杆菌检查和皮肤深层自体细菌检查,以了解机体的免疫反应性。
The occurrence and development of tumor lesions and the body’s own anti-infective forces (including anti-infection and anti-tumor defense factors) are closely linked. Defensive factors can be divided into specific and non-specific types. The latter include properdin, complement, lysozyme, etc. Lysozyme exists in body fluids, tissues, and cells. Reports have confirmed the upper respiratory tract and upper gastrointestinal malignant tumors. The patient’s lysozyme activity was significantly inhibited. Chemotherapy and radiotherapy also affect the body’s immune system. The authors studied the effect of lysozyme on anti-infectivity of patients with oropharyngeal malignancy during chemotherapy-radiotherapy. Forty-three cases of patients confirmed by pathology were examined and divided into two groups. One group received only chemotherapy-radiotherapy (21 cases), and the other group received chemotherapy-radiotherapy (n = 22). During the course of treatment, 0.5% was given twice a day. Lysozyme solution 5 ml for aerosol inhalation therapy. The examination method included the use of turbidimetric method for the determination of lysozyme activity in saliva and serum. In the second group of patients, oral E. coli examination and deep skin autologous bacterial examination were also performed to understand the body’s immunoreactivity.