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对陕西地区110例原发性肝癌(肝癌)患者按配对病例对照的设计方法进行了遗传流行病学研究。结果显示该地区肝癌的遗传度为27.6±3.6％,分离比为0.0016～0.0095。提示本地区肝癌发生中遗传因素所起的作用较小,并且不符合单基因的遗传方式。乙肝病毒(HBV)感染与癌家族史的分层分析表明HBV感染与癌家族史具有协同作用。分子遗传学分析表明,肝癌患者淋巴细胞DNA受诱癌剂作用后其UDS值明显增高,并且这种升高只表明在有癌家族史的肝癌患者中,提示肝癌的遗传易感染性可能与细胞DNA易受诱癌剂损伤和损伤后非程序合成增加有关。
A total of 110 cases of primary hepatocellular carcinoma (HCC) in Shaanxi Province were enrolled in the study of genetic epidemiology according to the design of paired case control. The results showed that the hereditary degree of HCC in this area was 27.6 ± 3.6% and the segregation ratio was 0.0016 ~ 0.0095. Prompt occurrence of liver cancer in the region genetic factors play a small role, and does not meet the single-gene heredity. Hierarchical analysis of hepatitis B virus (HBV) infection and cancer family history indicates that HBV infection has synergistic effects with cancer family history. Molecular genetic analysis showed that the liver cancer patients with lymphocyte DNA by the role of cancer-inducing agents UDS value was significantly higher, and this increase only shows that in patients with a family history of liver cancer, suggesting that the genetic susceptibility to liver cancer cells may be DNA is susceptible to injury induced by an inducer of cancer and an increase in non-programmed synthesis after injury.