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目的探讨血浆同型半胱氨酸(Hcy)与急性脑梗死的关系以及叶酸、VitB12干预的作用。方法 80例急性脑梗死患者作为观察组和同期80例健康体检者作为对照组,采用酶联免疫法测定血浆Hcy水平,脑梗死组筛选出高Hcy血症患者60例,再随机分为叶酸、VitB,治疗组30例及常规治疗组30例作对照研究。结果脑梗死组血浆Hcy水平明显高于对照组,高Hcy在脑梗死患者所占比率显著高于对照组,差异有统计学意义(P<0.01);叶酸、VitB,干预后治疗组血浆Hcy水平较治疗前明显下降(P<0.01)。结论血浆Hcy升高是急性脑梗死患者的重要危险因素,叶酸、VitB治疗可降低血浆Hcy水平,对预防和治疗脑梗死具有重要意义。
Objective To investigate the relationship between plasma homocysteine (Hcy) and acute cerebral infarction and the intervention of folic acid and VitB12. Methods Eighty patients with acute cerebral infarction were selected as the observation group and 80 healthy subjects at the same period as the control group. Plasma Hcy levels were determined by enzyme-linked immunosorbent assay (ELISA). Sixty patients with hyperhomocysteinemia were screened out in the cerebral infarction group. VitB, 30 cases of treatment group and 30 cases of conventional treatment group as a control study. Results The level of Hcy in the cerebral infarction group was significantly higher than that in the control group. The high Hcy in the cerebral infarction group was significantly higher than that in the control group (P <0.01) Than before treatment decreased significantly (P <0.01). Conclusion The elevated plasma Hcy is an important risk factor in patients with acute cerebral infarction. Folic acid and VitB treatment can reduce plasma Hcy level, which is of great significance in the prevention and treatment of cerebral infarction.