[目的 ]探讨O13 9群霍乱弧菌的L型变异。[方法 ]采用抗生素、胆盐和蒸馏水等实验室诱导方法进行观察。[结果 ]发现O13 9群霍乱弧菌MO45菌株经上述 3法诱导可发生L型变异 ,其菌落特征和菌体形态均与L型的描述相符。[结论 ]实验结果证实O13 9群霍乱弧菌可诱导成L型 ,其变异过程与ElTor弧菌相似 ,推测自然界中亦存在O13 9群霍乱弧菌的L型 [Objective] To investigate the L-type variation of Vibrio cholerae O13 9 group. [Method] The antibiotics, bile salts and distilled water were used to observe the laboratory induction method. [Result] It was found that strain L of V. cholerae O139 cholerae strain MO45 could induce L-shaped mutation induced by the above 3 methods. The characteristics of colony and morphology of the cells were consistent with the description of L type. [Conclusion] The experimental results confirmed that Vibrio cholerae O139 group can be induced into L type, and its variation process is similar to that of El Tor Vibrio. It is speculated that Vibrio cholera O139 group L type