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妊娠早、中期母体脂肪堆积,妊娠晚期母体脂肪分解以满足胎儿的快速生长。甘油三酯脂肪酶基因家族成员中的脂蛋白酯酶和内皮酯酶除了水解脂蛋白调节血脂变化外,还高表达在胎盘上,水解脂蛋白上的甘油三酯和磷脂以释放游离脂肪酸,使母体的脂质能够转运给胎儿。病理妊娠如肥胖、妊娠期糖尿病、胎儿生长受限和子痫前期的孕妇存在血脂异常,如高甘油三酯、高游离脂肪酸等变化。脂蛋白酯酶、内皮酯酶在病理妊娠孕妇中存在表达异常,与其脂质代谢变化及胎儿生长异常密切相关。
Early pregnancy, mid-term accumulation of maternal fat, maternal lipolysis in late pregnancy to meet the rapid growth of the fetus. Lipoprotein lipase and endoesterase in the triglyceride lipase gene family members in addition to lipoprotein lipoprotein regulation of lipid changes, but also high expression in the placenta, hydrolysis of lipoprotein triglycerides and phospholipids to release free fatty acids, so that The mother’s lipids can be transported to the fetus. Pathological pregnancy such as obesity, gestational diabetes, fetal growth restriction and preeclampsia pregnant women there are dyslipidemia, such as high triglycerides, high free fatty acids and other changes. Lipoprotein lipase, endoesterase expression in pregnant women with pathological abnormalities exist, and its lipid metabolism and fetal growth abnormalities are closely related.