论文部分内容阅读
目的:研究血脂与颈动脉斑块形成之间的临床关联。方法:收集2005年6月-2006年12月在本院检查颈动脉彩色多普勒超声的住院患者279例,分析其临床资料,先对颈总动脉的内膜-中层厚度(IMT)行多重回归、根据颈动脉有无斑块进行分组并行二项分类Logistic回归筛选其影响因素,再分析血脂四项指标与颈动脉的斑块积分、斑块指数及IMT之间的偏相关性分析,并比较有无斑块两组血脂四项指标的大小。并对血脂四项指标绘制ROC曲线评价其对颈动脉斑块的预测价值。结果:在对IMT的多重回归中低密度脂蛋白(LDL)被作为危险因素之一筛选出来(B=0.055,P=0.048),但在二项分类Logistic回归中血脂四项指标均被剔除。LDL与IMT之间呈正相关(r=0.120,P=0.048)。颈动脉有无斑块两组间血脂四项指标无统计学意义。四项指标的ROC曲线下面积均小于0.7(P均>0.05),对有无斑块形成没有预测价值。结论:LDL与颈动脉的IMT增厚有关,但血脂四项指标与颈动脉斑块的形成不平行,对颈动脉有无斑块形成没有预测价值。
PURPOSE: To study the clinical relevance of lipids and carotid plaque formation. Methods: A total of 279 hospitalized patients undergoing carotid color Doppler ultrasonography in our hospital from June 2005 to December 2006 were collected. Clinical data were analyzed. Multiple intima - media thickness (IMT) Regression, according to the carotid artery plaque grouping and parallel binary logistic regression screening of the influencing factors, and then analysis of four indicators of lipid and carotid plaque score, plaque index and IMT partial correlation analysis Compare the two groups of blood lipid four indicators size. ROC curve was drawn on the four indexes of blood lipids to evaluate the predictive value of carotid artery plaque. RESULTS: Low-density lipoprotein (LDL) was selected as one of the risk factors for multiple regression of IMT (B = 0.055, P = 0.048). However, all four indicators of blood lipid in the binomial Logistic regression were excluded. There was a positive correlation between LDL and IMT (r = 0.120, P = 0.048). No carotid artery plaque between the two groups of four indicators of blood lipids was not statistically significant. The area under the ROC curve of the four indexes was less than 0.7 (all P> 0.05), and had no predictive value for the presence or absence of plaque formation. Conclusion: LDL is related to IMT thickening of carotid artery. However, the four indexes of blood lipid are not parallel to the formation of carotid artery plaque, and there is no predictive value for carotid artery plaque formation.