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目的：探讨肿瘤坏死因子（Tumor Necrosis Factor a，TNFa）在妊娠期高血压疾病发病中的作用及其对胎儿生长发育的影响。方法：选取妊娠晚期重度子痫前期孕妇35例为研究组，正常足月妊娠25例为对照组，以放免方法测定母血、羊水、新生儿脐血中TNFa的含量及母血中层粘连蛋白（Laminin，LN）的含量。结果：妊高征组母血、脐血、羊水中TNFa水平明显高于正常对照组（p＜0.01），且母血TNF浓度最高，脐血次之，羊水最低；妊高征组母血LN水平明显高于正常对照组（p＜0.01），且与母血TNFa呈正相关（г=0.90，p＜0.001），而对照组两者无相关性（г=0.30，p＞0.05）；妊高征合并胎儿宫内生长受限（FGR）者母血、脐血、羊水中TNFa水平明显高于未合并FGR者，且两者均明显高于正常对照组（p＜0.05）.结论：①TNFa损伤血管内皮系统可能是妊高征发病机制中的一个重要方面。②妊高征时体内异常增高的的TNFa水平，加重胎儿宫内生长发育障碍，促进FGR的发生。“,”Objective:To investigate the role of tumor necrosis factorα(TNFα) in the pathogensis of pregnancy – induce hypertension (PIH) nd the growth of fetus .Methods:35 women with severe PIH were studied and 25 normal term – pregnant women as control . Maternal serum . Amniotic fluid and umbilical blood TNF in meternal serum , amniotic fluid and umbilical blood in the PIH group were significantly higher than those in the control group (P<0.01) . Maternal LN in PIH was previously higher than in control group (P<0.01) . There was a positive correlation ibetween TNF and LN of maternal serum in PIH ( r = 0.9 , P0.05 ) . Maternal serum , amniotic fluid and umbilical blood TNF levels in PIH with IUGR were obxiously higher than those in PIH without IUGR (P<0.05 ) , and the later were pobviously higher than those in control group (P<0.05 ) .Conclusion:① The injury of excessive release of TNF to endothelial cels may be a part of the pathogensis of PIH .② High level of TNF in PIH interfered with fetal growth and contributed to the development of IUGR .