【摘 要】
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目的 建立小型猪可复性肺不张模型的实验方法.方法 雄性实验用中国小型猪12只,随机分成肺不张组(A组,6只)和肺复张组(R组,6只).麻醉后经纤支镜经在右主支气管下端置入镍钛合
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目的 建立小型猪可复性肺不张模型的实验方法.方法 雄性实验用中国小型猪12只,随机分成肺不张组(A组,6只)和肺复张组(R组,6只).麻醉后经纤支镜经在右主支气管下端置入镍钛合金封堵器,R组在形成肺不张后再次纤支镜下取出封堵器,置入和取出封堵器后每3 dCT扫描观察肺不张形成和复张的情况变化,A组在确定肺不张的第3d处死,R组在肺不张3d取出封堵器后的2周时处死实验猪.结果 A组呈典型的肺不张病理学及CT改变,R组肺不张改变明显减轻,趋向正常.结论 小型猪纤支镜下右下肺置入/收回封堵器可建立可复性肺不张模型.
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