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目的观察重连口服液的解热作用及其对炎性递质的影响。方法将36只新西兰兔随机分为6组,即正常组,模型组,重连口服液低、中、高剂量组和布洛芬组,每组6只。连续给药4d,采用大肠杆菌内毒素注射法复制发热模型。于注射后0.5、1.0、2.0、3.0、4.0h分别观察各组兔直肠温度的变化,采用放射免疫法测定注射后4h各组血清肿瘤坏死因子-α(tumor necrosis factor alpha,TNF-α)、白细胞介素-1β(interleukin-1beta,IL-1β)和白细胞介素-6(interleukin-6,IL-6)水平。结果重连口服液低、中、高剂量组在注射后1.0、2.0、3.0、4.0h直肠温度升高值显著低于模型组(P<0.05,或P<0.01),其解热作用较布洛芬组起效慢,但退热维持时间较长。重连口服液高剂量组血清IL-1β、TNF-α、IL-6水平均较模型组显著降低(P<0.05,或P<0.01)。结论重连口服液具有显著的退热作用,其作用机制可能与其抑制炎性因子的释放有关。
Objective To observe the antipyretic effect of rehydration oral liquid and its effect on inflammatory neurotransmitter. Methods Thirty-six New Zealand white rabbits were randomly divided into 6 groups, namely normal group, model group, reperfusion oral low, medium and high dose groups and ibuprofen group, 6 in each group. Continuous administration of 4d, using E. coli endotoxin injection replication model fever. The changes of rectal temperature in each group were observed at 0.5, 1.0, 2.0, 3.0, 4.0 h after injection. The levels of tumor necrosis factor alpha (TNF-α) Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels were measured. Results The rectal temperature of 1.0,2.0,3.0,4.0 h after reperfusion in low, middle and high dose reperfusion group was significantly lower than that in model group (P <0.05 or P <0.01) The ibuprofen group started slowly but maintained for a longer time. Serum levels of IL-1β, TNF-α and IL-6 in high dose of rehydration oral liquid group were significantly lower than those in model group (P <0.05 or P <0.01). Conclusion The rehydration oral liquid has a significant antipyretic effect, and its mechanism may be related to the inhibition of the release of inflammatory cytokines.