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本法以分子内亲核取代反应来形成1,8-萘啶环,并用六水哌嗪代替单乙酰哌嗪,简化了工艺。各步收率较高,具有工业化的前景。
This method replaces intramolecular nucleophilic reactions to form 1,8-naphthyridine rings, and hexa-piperazine instead of monoacetyl-piperazine simplifies the process. Each step yield higher, with industrialization prospects.