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采用PAP免疫组化方法,对96例肝活检标本进行肝细胞内HBsAg和HBcAg免疫反应性定位,探讨肝细胞损伤程度与肝细胞内HBsAg和HBcAg表达的关系。结果显示:慢性活动型肝炎和肝硬变患者,肝细胞内HBsAg表达以膜型为主,HBcAg以浆膜型为主。慢性迁延型肝炎和HBV携带者,肝细胞内HBsAg以包涵体型为主,HBcAg则以核型为主。提示:肝细胞膜上表达的HBsAg和HBcAg可作为靶抗原,导致肝损伤。
The PAP immunohistochemical method was used to detect the immunoreactivity of HBsAg and HBcAg in hepatocytes of 96 cases of liver biopsy specimens to investigate the relationship between the degree of hepatocyte injury and the expression of HBsAg and HBcAg in hepatocytes. The results showed that in patients with chronic active hepatitis and cirrhosis, the expression of HBsAg in hepatocytes was dominated by membrane type, while the serotype of HBcAg was serosal type. Chronic persistent hepatitis and HBV carriers, HBsAg in hepatocytes to the inclusion body type, HBcAg karyotype based. Hint: HBsAg and HBcAg expressed on hepatocyte membrane can be used as target antigen, leading to liver injury.