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1 材料与方法 动物:Wistar大鼠,体重193.37±34.46g,雌雄兼备,均购自中山大学实验动物房。药物:将中药煎成水溶液(每毫升相当于生药1.5g),用药动物按8ml/kg灌胃。 大鼠应激性溃疡:采用束缚水浸应激法。动物随机分为用药组和模型组,每组8只,在实验的1h分别灌服加味半夏泻心汤和等量生理盐水;根据腺胃部出血点个数计算溃疡指数。
1 Materials and Methods Animals: Wistar rats weighing 193.37±34.46 g, both male and female, were purchased from experimental animals room of Sun Yat-sen University. Drugs: The Chinese medicine is decocted into an aqueous solution (equivalent to 1.5g of crude drug per milliliter), and the medication animal is intragastrically administered at 8ml/kg. Rat stress ulcers: The use of bound water immersion stress method. Animals were randomly divided into drug group and model group, with 8 rats in each group. Modified Banxia Xiexin Decoction and the same amount of normal saline were given at 1 hour after the experiment. The ulcer index was calculated according to the number of bleeding sites in the glandular stomach.