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双酚A(bisphenol A,BPA)是一种代表性的环境雌激素,其广泛使用所造成的严重危害越来越引起人们的关注。双酚A主要通过结合雌激素受体来干扰内源性雌激素的正常生理功能。大量研究结果表明,大脑发育关键期双酚A暴露不仅会影响神经干细胞的增殖,还会对其树突发育造成不可逆的危害;同时,在一定程度上影响少突胶质细胞、星型胶质细胞等神经胶质细胞的发育及功能。因此,深入探究临界期双酚A暴露对神经系统的影响及其具体的分子机制十分必要。
Bisphenol A (BPA) is a kind of representative environmental estrogen, and its serious harm caused by its widespread use attracts more and more attention. Bisphenol A interferes with the normal physiological function of endogenous estrogen mainly by binding to estrogen receptors. Numerous studies have shown that exposure of bisphenol A at the critical stage of brain development will not only affect the proliferation of neural stem cells but also cause irreversible damage to dendrites. At the same time, exposure to oligodendrocytes, astrocytes The development and function of glial cells such as stromal cells. Therefore, in-depth study of the critical period of bisphenol A exposure on the nervous system and its specific molecular mechanisms are necessary.