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目的了解山东省正常人群风疹病毒自然感染状况,为保护易感人群及制定合理的预防接种方案提供科学依据。方法采用间接酶联免疫吸附试验(ELISA)检测山东省部分地区正常人群血清中风疹病毒特异性抗体IgG。结果该人群RV-IgG阳性率为80.20%,其中,≤20岁组人群抗体的阳性率为66.87%,>20岁组人群抗体阳性率为82.86%,差异有统计学意义(P<0.05);男性人群抗体阳性率为77.37%,女性人群的抗体阳性率为83.37%,差异有显著性意义(P<0.05);不同职业及不同地区人群抗体阳性率的差异亦均有统计学意义(P<0.05,P<0.05)。结论低龄儿童和青少年风疹免疫水平较低,是风疹免疫的主要对象。育龄妇女也是风疹免疫的重点对象。不同的工作环境和生活习惯对风疹病毒的感染率有一定的影响。
Objective To understand the natural infection status of rubella virus in normal population in Shandong Province and provide scientific evidences for the protection of susceptible population and the development of a reasonable vaccination program. Methods The indirect ELISA was used to detect the serum specific rubella IgG in normal population of Shandong Province. Results The positive rate of RV-IgG in this population was 80.20%. The positive rate of antibody in people ≤20 years old was 66.87%, and the positive rate of antibody was 82.86% in those> 20 years old. The difference was statistically significant (P <0.05). The positive rate of antibody in male population was 77.37%, the positive rate of antibody in female population was 83.37%, the difference was significant (P <0.05); the difference of antibody positive rate among different occupations and different regions also had statistical significance (P < 0.05, P <0.05). Conclusion The level of rubella immunization in young children and adolescents is low, which is the main target of rubella immunization. Women of childbearing age are also the key targets of rubella immunity. Different working conditions and lifestyle have a certain impact on the infection rate of rubella virus.