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目的观察贝那普利(ACEI)与缬沙坦(ARB)联合应用对原发高血压患者尿蛋白排泄的影响。方法30例确诊的原发性高血压的患者,测定基础血压水平,24小时尿蛋白定量,经贝那普利治疗4周后再次测定24小时尿蛋白定量,然后加用缬沙坦治疗4周,观察24小时尿蛋白定量的变化。结果30例原发性高血压患者平均24小时尿蛋白定量0.7±0.5g/L。贝那普利10mg/d治疗后平均24小时尿蛋白定量0.5±0.4g/L(与治疗前P<0.01);联合应用缬沙坦80mg/d治疗4周后24小时尿蛋白定量0.3±0.3g/L与联合用前比较差异显著(P<0.01)。结论贝那普利与缬沙坦联合应用对原发性高血压减少尿蛋白排泄的作用优于贝那普利单独应用。
Objective To observe the effect of combination of benazepril (ACEI) and valsartan (ARB) on urinary protein excretion in patients with essential hypertension. Methods Thirty patients with confirmed essential hypertension were enrolled in this study. Baseline blood pressure (BP), 24-hour urinary protein (UA) quantitation were measured. Urinary protein was quantified 24 hours after treatment with benazepril and then with valsartan for 4 weeks , Observed 24-hour urinary protein quantitative changes. Results The average 24-hour urinary protein in 30 patients with essential hypertension was 0.7 ± 0.5g / L. The average proteinuria of urinary protein after benazepril 10mg / d for 24 hours was 0.5 ± 0.4g / L (P <0.01 before treatment); the urinary protein of 24 hours after the combination of valsartan 80mg / d was 0.3 ± 0.3 g / L compared with the pre-combination difference was significant (P <0.01). Conclusion The combination of benazepril and valsartan is superior to benazepril alone in reducing the urinary protein excretion in patients with essential hypertension.