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目的探讨非甾体类抗炎药相关性上消化道岀血的临床特点?椒ā⊙≡褚蚺谎蚝诒?就诊并行胃镜检查确诊的216例患者,分为NSAIDs组和非NSAIDs组,比较两组患者临床特点、内镜特点及幽门螺杆菌(HP)感染情况。结果结果显示两组患者的性别、岀血方式比较差异无显著性(P>0.05);而年龄、岀血前消化道症状、心血管病史、HP感染及内镜特点两组比较差异有显著性(P<0.05)。结论非甾体类抗炎药相关性上消化道岀血多见于老年人,有心血管病史,以粘膜糜烂及胃溃疡居多,HP感染增加了NSAIDs相关性胃黏膜损害。
Objective To investigate the clinical features of non-steroidal anti-inflammatory drug-related upper gastrointestinal bleeding.Patients were divided into NSAIDs group and non-NSAIDs group with 216 patients diagnosed by gastroscopy. The clinical features, endoscopic features and Helicobacter pylori (HP) infection were compared between the two groups. The results showed that there was no significant difference in gender and blood stasis between the two groups (P> 0.05), but there was significant difference between the two groups in terms of age, premalignanal gastrointestinal symptoms, cardiovascular history, HP infection and endoscopic features (P <0.05). Conclusion Non-steroidal anti-inflammatory drug-related upper gastrointestinal bleeding is more common in the elderly and has a history of cardiovascular disease. Mucosal erosion and gastric ulcer are predominant. HP infection increases NSAIDs-associated gastric mucosal damage.