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免疫因素是引起男性不育的原因之一,由手术、损伤、感染、化学或物理损伤等致生殖道黏膜、血-睾屏障、血-附睾屏障的破坏,可导致隐蔽的精子抗原突破生理屏障进入血液,触发抗精子抗体的产生。人抗精子抗体主要有3个亚类:IgG、IgA和IgM。IgA为精子凝集抗体0主要存在于精液中;IgG为精子制动抗体0主要存在于血清中;IgM可以固定补体0介导细胞溶解0促进精子凝集0从而影响精子功能。临床检测抗精子抗体方法有免疫珠结合试验(IBT)和酶联免疫吸附试验等。
Immune factors is one of the causes of male infertility, by surgery, injury, infection, chemical or physical damage caused by the reproductive tract mucosa, blood - testis barrier, blood - epididymal barrier can lead to hidden sperm antigens break through the physiological barrier Into the blood, trigger anti-sperm antibodies. There are three main human anti-sperm antibodies: IgG, IgA and IgM. IgA is sperm agglutination antibody 0 mainly present in semen; IgG is sperm brake antibody 0 mainly present in serum; IgM can fix complement 0-mediated cell lysis 0 to promote sperm agglutination 0 thus affecting sperm function. Clinical testing methods of anti-sperm antibodies have immune bead binding assay (IBT) and enzyme-linked immunosorbent assay.