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目的研究婴幼儿轮状病毒感染合并肝脏、心肌及神经系统等胃肠外脏器损害的关系。方法对254例住院腹泻患儿用金标法检测粪便轮状病毒抗原并做心肌酶及肝功检测,按照大便轮状病毒抗原检测结果分为观察组(大便轮状病毒抗原阳性)和对照组(大便轮状病毒抗原阴性),对其结果进行对比分析。结果观察组与对照组肝损害及心肌损害发生率比较差异有统计学意义(P<0.01),心肌损害及肝功能异常发生率与患儿发病年龄比较差异有统计学意义(P<0.01)。结论婴幼儿轮状病毒感染常合并心肌及肝损害,且年龄小者受损害几率较大,因此建议对轮状病毒感染患儿应常规完善心肌酶及肝功能检查,及时发现病情并给予有针对性的治疗。
Objective To study the relationship between rotavirus infection in infants and young children and the damage of extraintestinal organ such as liver, myocardium and nervous system. Methods A total of 254 inpatients with diarrhea admitted to hospital were tested for stool rotavirus antigen by gold standard method and myocardial enzymes and liver function tests were performed. According to the results of stool rotavirus antigen test, the observation group (stool rotavirus antigen positive) and control group (Stool rotavirus antigen negative), the results of comparative analysis. Results The incidences of liver damage and myocardial damage in observation group and control group were significantly different (P <0.01). The incidence of myocardial damage and abnormal liver function was significantly different from the onset age of children (P <0.01). Conclusion Infants and young children rotavirus infection often associated with myocardial and liver damage, and the younger the greater the risk of damage, it is recommended for children with rotavirus infection should be routinely improved myocardial enzymes and liver function tests, timely detection of the disease and given Sexual treatment.