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目的 :探讨淫羊藿甙 (ICA)对急性早幼粒白血病细胞端粒酶活性的影响。方法 :采用ICA与全反式维甲酸 (ATRA)对比试验 ,观察ICA对白血病细胞端粒酶活性及增殖分化的影响。结果 :ICA可明显抑制端粒酶活性 ,对白血病细胞均有较明显的诱导分化和抑制增殖作用 ,且与ATRA合用可产生明显的协同效应。结论 :ICA具有抑制急性早幼粒白血病细胞端粒酶活性的作用。
Objective: To investigate the effect of icariin (ICA) on telomerase activity in acute promyelocytic leukemia cells. Methods: ICA and all-trans retinoic acid (ATRA) contrast test to observe the impact of ICA on telomerase activity and proliferation and differentiation of leukemia cells. Results: ICA could significantly inhibit telomerase activity, induce differentiation and inhibit proliferation in leukemia cells, and produce synergistic effect with ATRA. Conclusion: ICA can inhibit telomerase activity in acute promyelocytic leukemia cells.