论文部分内容阅读
目的 调查艾滋病患者抗菌药物使用情况,了解不合理用药比例、原因及危害,为临床合理用药提供参考.方法 收集整理2017年7月我科出院患者的住院医嘱,对其中抗菌药物进行点评分析.结果 136例患者中,111例使用了抗菌药物(81.62％),其中治疗用药104例(93.69％),预防用药7例(6.31％).该月住院患者抗菌药物使用强度为324.82.47例(34.56％)患者合并结核或分枝杆菌感染,剔除抗结核药物,抗菌药物使用强度为228.49.使用频度最高的5种药物依次为氟康唑、复方磺胺甲噁唑片、青霉素钠、乙胺丁醇、异烟肼.使用抗菌药物的患者中,有43例(38.74％)存在用药不合理,涉及医嘱52条.不合理医嘱中50.00％为存在药物相互作用,13.46％为用法用量不适宜,11.54％为疗程过长.结论 艾滋病患者使用抗菌药物种类多,强度大,药物相互作用复杂,存在不合理用药问题.临床药师可在此积极发挥作用,促进抗菌药物合理使用.“,”Objective To investigate the antibacterial drugs in acquired immune deficiency syndrome(AIDS)inpatients,study the cause and damage of irrational drug use and provide reference for clinical rational drug use.Methods The medications of AIDS inpatients discharged from infectious diseases department during July 2017 were reviewed.Antibacterial drugs were summarized and irrational prescriptions were analyzed.Results Medications of 136 inpatients were reviewed,in which 111 patients (81 .62％)used antibacterial drugs induding 104 cases(93.69％)for therapeutic treatment and 7 cases (6.31 ％)for prevention.Forty-seven cases (34.56％)had tuberculosis or mycobacterium coinfection. Antibiotics use intensity was 324.82 in total and 228.49 excluding anti-tuberculosis drugs.Fluconazole, compound sulfamethoxazole,penicillin sodium,ethambutol and isoniazid were most frequently used.In patients using antibacterial drugs,43 patients(31 .62％)had 52 prescriptions of irrational drug use.Drug interaction accounted for 50.00％,the inappropriate dosage accounted for 13.46％ and the too long course of treatment accounted for 11 .54％.Conclusion There are still many irrational drug use in AIDS patients because of a variety and high intensity use of antibacterial and complex drug interactions.Clinical pharmacists could play a positive role in promoting rational use of antibacterial drugs.