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目的:探讨紫杉醇药物涂层球囊治疗冠状动脉狭窄的远期临床疗效。方法:选择辽宁省金秋医院2015年8月至2017年11月行冠状动脉内超声引导下实施紫杉醇药物涂层球囊扩张治疗的冠状动脉狭窄患者8例，患者均随访观察，并于术后12～36个月[26.5(14.5～32.5)个月]行冠状动脉造影检查。结果:8例患者均行紫杉醇药物涂层球囊扩张成形术，术中未出现影响血流的夹层，普通球囊扩张后即刻行冠状动脉内超声检查准确测量冠状动脉血管内径及病变长度，并应用紫杉醇药物涂层球囊对冠状动脉狭窄病变进行球囊扩张治疗，药物涂层球囊介入治疗的即刻成功率为100.00%，术后比术前病变狭窄程度明显减轻[20.00%(11.25%～25.00%)比90.00%(80.00%～97.75%)，n H＝11.549，n P<0.01]；术后比术前病变冠状动脉最小内径明显增大[2.23(2.03～2.53)mm比0.30(0.25～0.54)mm，n H＝11.361，n P<0.01]。术后患者住院期间无心绞痛再发、无其他心血管不良事件发生。随访期间有1例患者曾再发心绞痛，程度较前减轻，经药物治疗后好转；1例患者复查冠状动脉造影显示冠状动脉再发狭窄，于原狭窄处植入支架治疗；1例患者复查冠状动脉造影显示冠状动脉血管闭塞侧支循环形成，未予治疗。n 结论:紫杉醇药物涂层球囊直接用于治疗冠状动脉狭窄病变是安全有效的，提供了一个“有介入无植入”的冠心病治疗的有效手段。冠状动脉内超声检查为药物涂层球囊扩张成形治疗提供了重要的指导作用，保证了介入治疗的效果及安全性。紫杉醇药物涂层球囊治疗的远期效果是乐观的，而对于冠状动脉出现再狭窄的患者可以直接植入药物洗脱支架治疗。“,”Objective:To summarize the long-term clinical effect of paclitaxel drug-coated balloon in the treatment of patients with coronary stenosis lesions.Methods:From August 2015 to November 2017, 8 patients with coronary stenosis lesions in Jinqiu Hospital of Liaoning Province were selected and they received the percutaneous transluminal coronary angioplasty(PTCA) with paclitaxel drug-coated balloon under intravascular ultrasound-guided.All 8 patients had coronary angiography at 12-36 months[26.5(14.5~32.5) months]after operation and the outcomes of follow-up were analyzed.Results:Intravascular ultrasound was done after PTCA with ordinary balloon before the paclitaxel drug-coated balloon angioplasty.There were no interlayers which affected blood flow after PTCA with ordinary balloon before the paclitaxel drug-coated balloon angioplasty.The success rate of immediate intervention operation was 100.00%.The lesion degree of stenosis lesions and the minimum diameter at postoperation and preoperation had statistically significant differences[20.00%(11.25%~25.00%) vs.90.00%(80.00%~97.75%), n H=11.549, n P<0.01; 2.23(2.03~2.53)mm vs.0.30(0.25~0.54)mm,n H=11.361, n P<0.01]. There were no adverse cardiovascular events during the duration of hospital stay after the intervention operation.During follow-up, one patient with angina recurrence was cured by drugs, one patient received stent implantation because of coronary restenosis, one patient with coronary artery occlusion received no stent implantation because of lateral branch forming.n Conclusion:Paclitaxel drug-coated balloon is effective in the treatment of patients with coronary stenosis lesions.It is one new method named “ the intervention without permanent implant” that the paclitaxel drug-coated balloon expands.It is helpful to safety and effect under intravascular ultrasound-guided.The long-term effect is optimistic and the patients with coronary restenosis can receive drug-eluting stent implant.