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目的探讨介入治疗对冠心病患者血浆单核细胞趋化因子-1(MCF-1)、肿瘤坏死因子α(TNF-α)及术后再狭窄的影响。方法选择经冠状动脉(冠脉)介入治疗单支病变的冠心病心绞痛患者70例(介入组),包括不稳定型心绞痛38例,稳定型心绞痛32例;冠脉造影结果正常的受试者40例作为对照组。采用酶联免疫吸附法检测对照组及介入组治疗前后MCF-1和TNF-α水平并进行比较。结果治疗前后血浆MCF-1介入组分别为(19.49±4.64)pg/L、(21.99±4.71)pg/L,差异有统计学意义(P<0.01);对照组分别为(17.78±4.42)pg/L、(18.41±4.45)pg/L,差异无统计学意义(P>0.05)。治疗前后血浆TNF-α介入组分别为(15.60±4.89)μg/L、(19.96±5.01)μg/L,差异有统计学意义(P<0.01);对照组分别为(13.50±5.56)μg/L、(14.05±5.68)μg/L,差异无统计学意义(P>0.05)。介入组治疗前后血浆MCF-1、TNF-α水平均显著高于对照组,差异有统计学意义(P<0.05)。结论冠脉介入治疗促进冠心病心绞痛患者血浆MCF-1及TNF-α水平的升高,是否为介入治疗术后支架内再狭窄的重要机制之一尚待进一步论证。
Objective To investigate the effects of interventional therapy on plasma levels of monocyte chemoattractant factor-1 (MCF-1), tumor necrosis factor-α (TNF-α) and postoperative restenosis in patients with coronary heart disease. Methods Seventy patients (intervention group) with coronary artery angina pectoris who underwent single coronary artery coronary intervention were enrolled in the study. They included 38 unstable angina pectoris patients and 32 stable angina pectoris patients. The subjects with normal coronary angiography Cases as a control group. The levels of MCF-1 and TNF-α in control group and intervention group before and after treatment were detected by enzyme-linked immunosorbent assay and compared. Results The plasma levels of MCF-1 in the intervention group before and after treatment were (19.49 ± 4.64) pg / L and (21.99 ± 4.71) pg / L, respectively, with statistical significance (P <0.01) /L, (18.41 ± 4.45) pg / L, the difference was not statistically significant (P> 0.05). The levels of TNF-α in the intervention group before and after treatment were (15.60 ± 4.89) μg / L and (19.96 ± 5.01) μg / L respectively, with statistical significance (P <0.01) L, (14.05 ± 5.68) μg / L, the difference was not statistically significant (P> 0.05). The plasma levels of MCF-1 and TNF-α in the intervention group before and after treatment were significantly higher than those in the control group, with statistical significance (P <0.05). Conclusions Coronary intervention may promote the increase of plasma levels of MCF-1 and TNF-α in patients with coronary heart disease and angina pectoris. Whether this is an important mechanism of in-stent restenosis after percutaneous coronary intervention remains to be further elucidated.