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目的探讨奥美拉唑与抗生素结合治疗慢性胃炎的临床应用价值。方法 85例慢性胃炎患者,参照治疗方案的差异性分为参照组(40例)与研究组(45例)。参照组给予克拉霉素治疗,研究组在参照组基础上加用奥美拉唑治疗。对比两组的临床效果。结果研究组总有效率95.6%高于参照组的72.5%,差异具有统计学意义(P<0.05)。研究组发生腹痛1例、反酸2例、嗳气2例、腹胀1例,显著少于参照组的6、8、9、6例,差异均具有统计学意义(P<0.05)。研究组不良反应发生率4.4%与参照组的7.5%比较差异无统计学意义(P>0.05)。结论对慢性胃炎患者采用奥美拉唑联合抗生素治疗,可降低不良反应发生率,改观患者临床表现,可在临床上加以推广。
Objective To investigate the clinical value of omeprazole combined with antibiotics in the treatment of chronic gastritis. Methods Eighty-five patients with chronic gastritis were divided into the reference group (n = 40) and the study group (n = 45) according to the difference of treatment regimens. The reference group was treated with clarithromycin, and the study group was treated with omeprazole on the basis of the reference group. The clinical effects of two groups were compared. Results The total effective rate of the study group was 95.6% higher than that of the reference group (72.5%), the difference was statistically significant (P <0.05). The study group had 1 case of abdominal pain, 2 cases of acid reflux, 2 cases of belching, 1 case of abdominal distension, significantly less than the 6,8,9,6 cases of the reference group, the differences were statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the study group and the reference group (4.4% vs. 7.5%, P> 0.05). Conclusion Omeprazole combined with antibiotics in patients with chronic gastritis can reduce the incidence of adverse reactions and improve the clinical manifestations of patients, which can be popularized clinically.