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本刊讯甲氧氯普胺是一种多巴胺受体拮抗药,可直接作用于延髓催吐化学感受区,同时还具有五羟色胺3(5-HT3)受体拮抗药特性,其适应证包括慢性胃炎、胃下垂以及功能消化不良等引起的腹胀、腹痛、嗳气;胃排空延缓以及糖尿病性胃排空障碍;以及手术、化疗、外伤、颅脑损伤等引起的恶心和呕吐等。目前,我国批准的甲氧氯普胺制剂包括片剂、口服液、注射剂、栓剂等。2014年国家药品不良反应监测数据库共收到甲氧氯普胺
Metoclopramide is a dopamine receptor antagonist that can act directly on the medullary emetic chemosensory region, but also has serotonin 3 (5-HT3) receptor antagonist properties, its indications include chronic gastritis, Gastroptosis and dyspepsia, abdominal distention, abdominal pain, belching, delayed gastric emptying and diabetic gastric emptying disorders, and nausea and vomiting caused by surgery, chemotherapy, trauma, craniocerebral injury and the like. At present, China’s approved metoclopramide preparations include tablets, oral liquid, injection, suppository and so on. Metoclopramide was received in the 2014 National Adverse Drug Reaction Monitoring Database