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目的:研究泮托拉唑与奥美拉唑治疗消化性溃疡的疗效及安全性。方法:经胃镜证实的消化性溃疡患者随机分成泮托拉唑组(治疗组)62例和奥美拉唑组(对照组)58例。治疗组泮托拉唑40mg,po,qn,对照组用药为奥美拉唑20mg,po,qn。十二指肠溃疡患者疗程4周,胃溃疡患者疗程6周。停药后均复查胃镜观察溃疡愈合情况。症状改善及副作用发生情况。结果:十二指肠溃疡的愈合率两组分别为92.1%和94.7%,胃溃疡的愈合率两组分别为91.7%和90%(P均>0.05)。各项症状的改善情况两组无统计学差异。副作用的发生率两组分别为9.7%和8.6%(P>0.05)。结论:泮托拉唑对消化性溃疡有较高的治愈率和良好的症状改善情况,其疗效和副作用与奥美拉唑相当。
Objective: To study the efficacy and safety of pantoprazole and omeprazole in the treatment of peptic ulcer. Methods: Gastroscopy confirmed patients with peptic ulcer were randomly divided into pantoprazole group (treatment group) 62 cases and omeprazole group (control group) 58 cases. Treatment group pantoprazole 40mg, po, qn, the control group was omeprazole 20mg, po, qn. Patients with duodenal ulcer treatment for 4 weeks, patients with gastric ulcer for 6 weeks. Gastroscopy was followed up after stopping the observation of ulcer healing. Symptoms and side effects of the situation. Results: The healing rate of duodenal ulcer was 92.1% and 94.7% in both groups. The healing rate of gastric ulcer was 91.7% and 90% in both groups (P> 0.05). The improvement of the symptoms of both groups was no significant difference. The incidence of side effects were 9.7% and 8.6% in both groups (P> 0.05). Conclusion: Pantoprazole has higher cure rate and good symptom improvement on peptic ulcer, its curative effect and side effect are comparable with omeprazole.