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急性胰腺炎时蛋白酶由胰腺释放进入周围组织和血循环,蛋白水解酶如胰蛋白酶钠以及其它因素如各种异体物质、低灌注、高热、机械创伤等都引起组织改变,从而激活补体系统的瀑布样反应(cascade),在这个反应中,补体C3、C5被激活成为过敏毒素C3a和C5a.C3a和C5a使血管通透性增加,平滑肌收缩,肥大细胞和嗜碱细胞释放组织胺,并可能影响心功能.在另一方面,过敏毒素灭活因子(AI)可使C3a、C5a灭活形成C3a desArg和C5a desArg.C3a desArg无活性,C5a desArg作为一种过敏毒素部分无活性,但能刺激中性白细胞.同时,补体激活还产生
Acute pancreatitis protease released into the surrounding tissues and blood circulation by the pancreas, proteolytic enzymes such as trypsin sodium and other factors such as allogeneic substances, hypoperfusion, hyperthermia, mechanical trauma and so cause tissue changes, thus activating the complement system of waterfall-like In this reaction, complement C3, C5 is activated to become anaphylatoxins C3a and C5a. C3a and C5a increase vascular permeability, smooth muscle contraction, histamine release from mast cells and basophils, and may affect heart On the other hand, anaphylatoxin inactivating factor (AI) inactivates C3a and C5a to form C3a desArg and C5a desArg. C3a desArg is inactive, while C5a desArg is partially inactive as an anaphylatoxin but stimulates neutral White blood cells at the same time, complement activation also produced