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目的观察肺表面活性物质联合机械通气在治疗新生儿呼吸窘迫综合征(NRDS)中的临床价值及疗效。方法将126例NRDS随机分组,其中A组64例给与肺表面活性物质联合机械通气治疗,B组22例给与肺表面活性物质(固尔苏)治疗,C组40例给与械通气治疗,观察治疗前后氧合指数(PaO2/FO2)、氧分压(PaO2)、二氧化碳分压(Pa-CO2)、pH值等指标变化。结果不同治疗方法对PaO2、PaCO2、PaO2/FO2、pH值的影响不同(F=3.25,F=3.31,F=3.42,F=0.73,P﹤0.05),A组明显优于其他两组(P﹤0.05);用药后不同时间PaO2、PaCO2、PaO2/FO2、pH值不同(F=3.87,F=3.42,F=3.53,F=0.84,P﹤0.05),PaO2、PaO2/FO2、pH值随时间延续治疗后不同时间点测量值均较治疗前升高(除pH值6h和12h时比较P﹥0.05外,其余P﹤0.05),PaCO2值随时间延续治疗后不同时间点测量值均较治疗前下降(P﹤0.05)。结论肺表面活性物质联合机械通气治疗NRDS在治疗后早期即能改善患儿PaO2/FO2、PaO2、PaCO,避免了病变的进一步加重,对降低患儿病死率具有重要意义。
Objective To observe the clinical value and efficacy of pulmonary surfactant combined with mechanical ventilation in the treatment of neonatal respiratory distress syndrome (NRDS). Methods 126 cases of NRDS were randomly divided into group A and group B, 64 cases were treated with pulmonary surfactant combined mechanical ventilation, 22 cases were treated with pulmonary surfactant (Cureth SU) in group B, and 40 cases were given mechanical ventilation The changes of PaO2 / FO2, PaO2, Pa-CO2 and pH before and after treatment were observed. Results The effects of different treatments on PaO2, PaCO2, PaO2 / FO2 and pH value were different (F = 3.25, F = 3.31, F = 3.42, F = 0.73, P < (P <0.05). PaO2, PaCO 2, PaO 2 / F 2 O and pH value were different at different time after treatment (F = 3.87, F = 3.42, F = 3.53, F = The measured values at different time points after treatment were higher than those before treatment (P <0.05 except at 6h and 12h, P <0.05, P <0.05), and the measured value of PaCO2 at different time points after treatment Before falling (P <0.05). Conclusion Pulmonary surfactant combined with mechanical ventilation can improve PaO2 / FO2, PaO2 and PaCO in children early after treatment, and avoid further aggravating of disease. It is of great significance to reduce the mortality of children.