目的观察化疗联合胸腔内注射沙培林治疗肺癌伴大量胸腔积液疗效。方法在常规化疗的基础上,抽胸水后胸腔内注射沙培林。结果肺癌总有效率42.5%;胸腔积液的有效率82.5%;毒副作用主要是骨髓抑制、消化道反应和脱发。结论肺癌伴大量胸腔积液常规化疗的同时胸腔内注射沙培林,方法简单、有效。 Objective To observe the effect of chemotherapy combined with intrapleural injection of samplin on lung cancer with pleural effusion. Methods Based on routine chemotherapy, pleural fluid was injected into the chest cavity after pleural effusion. Results The total effective rate of lung cancer was 42.5%. The effective rate of pleural effusion was 82.5%. The toxic and side effects were mainly myelosuppression, gastrointestinal reaction and hair loss. Conclusions Lung cancer with large pleural effusion routine chemotherapy while intrapleural injection of saponins, the method is simple and effective.