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目的:探讨中性粒细胞表面标志物CD64在小儿获得性肺炎疾病中的表达及意义。方法:选取我院儿科感染社区获得性肺炎患儿116例,分为细菌感染组30例,支原体感染组30例;所有入组患儿检测CRP水平及CD64表达量,采用SPSS 16.0统计软件对实验结果进行统计学分析。结果:与正常对照组相比,细菌感染组、支原体感染组CD64水平均明显增高,其中细菌感染组差异具有统计学意义(P<0.05);ROC曲线提示CD64诊断细菌感染的敏感度为89.21%,特异度为78.35%;诊断支原体感染的敏感度为67.51%,特异度为88.45%。结论:中性粒细胞表面标志物CD64可做为由细菌感染引起的小儿获得性肺炎的实验室检测及诊断依据。
Objective: To investigate the expression and significance of neutrophil surface marker CD64 in children with acquired pneumonia. Methods: A total of 116 children with community-acquired pneumonia were selected from our hospital for pediatric infection. They were divided into bacterial infection group (30 cases) and mycoplasma infection group (30 case). CRP levels and CD64 expression were detected in all children. SPSS 16.0 statistical software Results were statistically analyzed. Results: Compared with normal control group, the levels of CD64 in bacterial infection group and mycoplasma infection group were significantly increased, and the difference was statistically significant (P <0.05). The ROC curve indicated that the sensitivity of CD64 in the diagnosis of bacterial infection was 89.21% , The specificity was 78.35%. The sensitivity of mycoplasma infection was 67.51% and the specificity was 88.45%. CONCLUSION: Neutrophil surface marker CD64 can be used as a laboratory test and diagnosis basis for pediatric acquired pneumonia caused by bacterial infection.