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目的研究长方案中HCG日雌二醇(E2)和获卵数的比值与IVF-ET妊娠结局的关系。方法回顾性分析2011年6月-2011年10月在我中心行IVF/ICSI-ET共278个周期的临床资料,均采用黄体中期长方案,根据患者HCG日E2浓度和获卵数的比值分为3组,A组:E2/获卵数<200pg/ml;B组:E2/获卵数200-500pg/ml;C组:E2/获卵数>500pg/ml。比较3组患者的基本资料,IVF/ICSI过程中的临床参数和妊娠结局。结果 3组患者Gn天数,Gn总量,受精率,优胚率无统计学差异;妊娠率,种植率C组最低,与A,B组相比有统计学意义,宫外孕率A组最高,与B组比较差异有显著性,流产率C组高于B组(P<0.05),OHSS发生率C组最低(P<0.05)。结论 HCG日雌二醇(E2)和获卵数的比值会影响长方案的妊娠结局,此值>500pg/ml会降低妊娠率,种植率,且增加流产率。
Objective To study the relationship between the ratio of estradiol (E2) on HCG day and the number of oocytes retrieved in the long-term regimen and the pregnancy outcome of IVF-ET. Methods The clinical data of 278 cycles of IVF / ICSI-ET in our center from June 2011 to October 2011 were retrospectively analyzed. The mid-term luteal phase protocol was used. According to the ratio of E2 concentration on the HCG day to the number of oocytes retrieved Group A: E2 / number of oocytes <200 pg / ml; Group B: E2 / number of oocytes retrieved 200-500 pg / ml; Group C: E2 / number of oocytes retrieved> 500 pg / ml. The basic data of three groups of patients were compared, the clinical parameters in IVF / ICSI and pregnancy outcomes. Results The Gn days, Gn total, fertilization rate and excellent embryo rate in the three groups had no significant difference. The pregnancy rate and implantation rate were the lowest in group C, which were statistically significant compared with group A and group B. The rate of ectopic pregnancy was the highest in group A, There was significant difference between group B and group B (P <0.05). The incidence of OHSS in group C was the lowest (P <0.05). Conclusions The ratio of estradiol (E2) on the day of HCG to the number of oocytes will affect the pregnancy outcome of the long-term regimen. The value of> 500 pg / ml will reduce the pregnancy rate and implantation rate and increase the abortion rate.