原发性干燥综合征(prim ary Sj觟gren’s syndrom e,pSS)是常见的风湿性疾病,可累及多个器官系统。但合并凝血因子Ⅷ抗体形成,以出血为主要表现者极为罕见,现将我科收治的1例报告如下。患者女,37岁。入院前3个月出现双下肢瘀点、瘀斑,牙龈出血,月经量增多,5d前因头痛、呕吐急诊 Primary ary syndrome (prim ary Sjögren’s syndrom e, pSS) is a common rheumatic disease that can affect multiple organ systems. However, the formation of coagulation factor Ⅷ antibody to bleeding as the main performance is extremely rare, now we receive a case report is as follows. Female patient, 37 years old. Three months before admission, there were double lower extremity petechiae, ecchymosis, bleeding gums and increased menstrual flow. Headache and vomiting emergency